When they first meet, well-educated, timid, upper-class white guy cold pill Drix and uneducated, brash, buttcrack-class black guy white blood cell Ozzy have trouble getting along, but they are ultimately able to tear through their racial cell membranes. The CGI out-of-towner sticks out like a sore thumb riding shotgun down the crowded capillaries of Frank's animated anthropomorphic anatomy, out of his Ivy League petri dish element. After the brain cell jogs his memory why he's an incel cell, there's a gust of cherry flavor as Ozzy meets his new partner Drixenol "Drix" Koldreliff ( David Hyde Pierce), a Metroshka doll-like cell-sized pill who emerges from within a bigger pill. Arriving at the stomach port, Ozzy passes through a full-body X-ray scanner, a rather novel idea for mid-2001, running into the Mayor's secretary Leah (Brandy Norwood), who has cytoplasm in all the right places. Afraid that Frank's daughter is going to have him go to the hospital and cause a bodywide panic by substantiating the rumors of a deadly virus, Phlegmming hits the emergency override and has Frank take a cold pill of Drixenol. Meanwhile in city hall, Mayor Phlegmming ( William Shatner) is busy pretending to care about his constituents as he faces a reelection campaign against the infinitely more charismatic empty suit Tom Colonic ( Ron Howard). Shane is about to call the doctor as Frank self-medicates with some delicious KFC. Deadly virus Thrax ( Laurence Fishburne) emerges from the muck and slashes his way through the workers, spilling their cytoplasm as their boat circles down into Frank's throat. Meanwhile, an unsuspecting cattle prod-equipped cleanup crew in the mouth picks up the filthy egg that Frank had previously eaten.
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The police chief (Dennis Franz) is pissed, ready to bust Ozzy back down to the ass crack he came from or make him scab security.
Unfortunately the hot-blooded cop fires at his target with his globular orange gat but misses, blowing out a power station and giving Frank a nerve cramp.
He goes in homeostasis-optimal body temperature pursuit of suspects, in a lengthy chase that takes him all the way down to Frank's right leg. We are introduced to Osmosis "Ozzy" Jones ( Chris Rock), an African-American white blood cell heartbeat cop running immunity, stationed in the mouth and on the lookout for germs and viruses. Inside Frank's body is the titular City of Frank, a bustling metropolis inhabited by billions of microorganisms presumably the peace in the Middle Ear we see briefly advertised later became the War on Acute Otitis Media, but that's another story for the sequel that no one wants to see.
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Many fans of the movie found Thrax to be attractive (if Tumblr is any indication), despite him being barely humanoid. Feature Animation, who naively hoped to find success at the antidote antipode to The Iron Giant, though it certainly wouldn't be their last multi-million-dollar mistake as Warner continued to struggle with long-term illness and creative decisions indicative of degenerative brain damage from late-stage Rabbititis. The film was the fourth in a string of financial failures by Warner Bros. Osmosis Jones was met with mixed reviews, with critics praising the fun and educational animated portions but criticizing the live-action portions, their degradation of national treasure Bill Murray, and their use of sub- Will Ferrell grossout humor featuring exploding zits. Ultimately, Jones is caught in a cardiac triad, and must decide between his best friend Drix, Big Daddy Thrax, and Mayor Shatner's curvaceous secretary Leah. The two must break down the racial cell walls and prevent seductive virus Thrax from killing their host body - slovenly zookeeper and deadbeat dad Frank DeTorre - within forty-eight hours. It centers on Osmosis "Ozzy" Jones, an African-American white blood cell cop who complains that germs are trying to oppress him with viruses and infections, and Drixenol "Drix" Koldreliff, a whitebread cold pill straight outta the FDA who is no match for Ozzy's utter hipness and spleenwise attitude. Osmosis Jones is a 2001 American live-action/animated body cop comedy film with remedial animated scenes directed by Tom Sito and Piet Kroon and sickening live-action scenes directed by the Farrelly Brothers (though the commercials, end credits, and product descriptions outright lie to you and claim the Farrellys were the movie's "main" directors). “You know, this still isn't the most scientifically inaccurate thing I've ever worked on.” Note the Y2K-era futuristic tagline font and teeth-achingly bad puns.
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